HBEGF anticorps (AA 51-150)

N° du produit ABIN701050

Cet anticorps Lapin Polyclonal détecte spécifiquement HBEGF dans ELISA, IF (cc) et IHC (p). Il présente une réactivité avec des échantillons de Humain, Souris et Rat.Il a été cité dans 1 publication.

Aperçu rapide pour HBEGF anticorps (AA 51-150) (ABIN701050)

Antigène: HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HBEGF est non-conjugé

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-HBEGF anticorps

Épitope: AA 51-150

Réactivité croisée: Humain, Souris, Rat

Homologie: Dog,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human HB-EGF/DTSF

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-HBEGF (ABIN701050)

Lebkuechner, Wilhelmsson, Möllerström, Pekna, Pekny: "Heterogeneity of Notch signaling in astrocytes and the effects of GFAP and vimentin deficiency." dans: Journal of neurochemistry, (2015) (PubMed).

Détails sur HBEGF

Antigène: HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))

Autre désignation: HB-EGF

Sujet:

Synonyms: DTR, DTS, DTSF, HEGFL, Proheparin-binding EGF-like growth factor, HBEGF

Background: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

ID gène: 1839

UniProt: Q99075

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway