MAS1 anticorps (3rd Intracellular Loop)

N° du produit ABIN7042920

Cet anticorps anti-MAS1 Polyclonal Lapin (ABIN7042920) détecte spécifiquement MAS1 dans WB, IHC, IF et IC. L’anticorps est réactif avec des échantillons de Rat.

Aperçu rapide pour MAS1 anticorps (3rd Intracellular Loop) (ABIN7042920)

Antigène: MAS1 (MAS1 Oncogene (MAS1))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAS1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC)

Classe de qualité: KO Validated

Détail du produit anti-MAS1 anticorps

Épitope: 3rd Intracellular Loop, AA 212-224

Fonction: A Rabbit Polyclonal Antibody to Angiotensin-(1-7) Mas Receptor

Réactivité croisée: Humain, Souris, Rat

Homologie: Mouse,human - identical

Attributs du produit: Anti-Angiotensin-(1-7) Mas Receptor Antibody (ABIN7042920, ABIN7043904 and ABIN7043905) is a highly specific antibody designed against an epitope of the rat protein. The antibody can be used in western blot, immunocytochemistry, and immunohistochemistry applications. It has been designed to recognize Ang-(1-7) Mas receptor from rat, mouse, and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)KIRKNTWASHSSK, corresponding to amino acid residues 212-224 of the rat Angiotensin-(1-7) Mas receptor

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:100

IP: The optimal concentration should be determined by the user

Commentaires:

Cited Application: IHC|ICC|IFC

Negative Control: (ABIN7234720)

Blocking Peptide: (ABIN7234720)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur MAS1

Antigène: MAS1 (MAS1 Oncogene (MAS1))

Autre désignation: MAS1

Sujet:

Synonyms: Proto-oncogene Mas, MAS1

Description: The Angiotensin-(1-7) Mas receptor is the recently identified receptor of the biologically active heptapeptide Angiotensin-(1-7).1Angiotensin (Ang)-(1-7) is a metabolite of the well known peptide hormone Angiotensin (Ang) II, a key component of the renin-angiotensin system (RAS) that has a central role in cardiovascular homeostasis.Considerably interest in Ang-(1-7) and its receptor aroused in the last few years since it became apparent that it can counterbalance most of Ang II effects. Thus Ang-(1-7) has vasodilator and hypotensive effects as well as antiarrhythmic and cardioprotective roles.2, 3The Ang-(1-7) Mas receptor belongs to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily and was originally described as a protooncogene.Signaling via the Ang-(1-7) Mas receptor is still poorly elucidated however, evidence indicates that the receptor is coupled to a Gq/11 protein that activates phospholipase C (PLC).2,3The Ang-(1-7) Mas receptor is expressed in several organs including heart, kidney, blood vessels, testis and brain. Studies with Ang-(1-7) Mas receptor knockout mice have demonstrated the key role of this receptor in cardiovascular regulation as well as in the regulation of learning and memory.2

ID gène: 25153

NCBI Accession: NM_002377

UniProt: P12526

Pathways: ACE Inhibitor Pathway, Regulation of Carbohydrate Metabolic Process