CCKBR anticorps (Extracellular, N-Term)

N° du produit ABIN7043059

Cet anticorps Lapin Polyclonal détecte spécifiquement CCKBR dans WB, IHC, FACS et LCI. Il présente une réactivité avec des échantillons de Souris.

Aperçu rapide pour CCKBR anticorps (Extracellular, N-Term) (ABIN7043059)

Antigène: CCKBR (Cholecystokinin B Receptor (CCKBR))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CCKBR est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Détail du produit anti-CCKBR anticorps

Épitope: AA 39-53, Extracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to the Cholecystokinin B Receptor

Réactivité croisée: Humain, Souris, Rat

Homologie: human - 13,Rat - 14,15 amino acid residues identical

Attributs du produit: Anti-CCKBR (extracellular) Antibody (ABIN7043059, ABIN7044183 and ABIN7044184) is a highly specific antibody directed against an epitope of the mouse cholecystokinin B receptor. The antibody can be used in western blot, indirect flow cytometry, and immunohistochemistry applications. It has been designed to recognize CCKBR from mouse, rat, and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: CETPRIRGTGTRELE, corresponding to amino acid residues 39-53 of mouse Gastrin/cholecystokinin type B receptor

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:100-1:200

IP: The optimal concentration should be determined by the user

Commentaires:

Cited Application: IFC

Negative Control: (ABIN7235114)

Blocking Peptide: (ABIN7235114)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur CCKBR

Antigène: CCKBR (Cholecystokinin B Receptor (CCKBR))

Autre désignation: CCKBR

Sujet:

Synonyms: Cholecystokinin B receptor, Gastrin receptor, CCK2R, GASR

Description: Cholecystokinin B receptor (CCKBR), also known as the Gastrin receptor and CCKR2, belongs to the 7-transmembrane domain, G-protein coupled receptor (GPCR) superfamily, and is one of the two receptors that mediates the effects of the cholecystokinin (CCK) and gastrin peptides1,2.CCK and gastrin are related linear peptides that occur in different forms but share the last five C-terminal amino acid residues. CCK regulates several nutritional-related activities such as stimulation of pancreatic exocrine secretion or the regulation of intestinal transit, while gastrin's main function is the stimulation of gastric acid secretion1,2.Both CCKBR and the other CCK receptor (CCKAR or CCK1R) are coupled to a Gq/11 protein that activates phospholipase C (PLC) and leads to production of inositol 1,4,5-trisphosphate (InsP3), and intracellular Ca2+mobilization.CCKBR was originally identified in the brain (and hence its name, type B for Brain) where it is widely distributed, notably in the cerebral cortex and striatum. In the periphery, CCKBR is most notably expressed in acid secreting cells in the mucosa of the stomach. The tissue distribution of CCKBR corresponds to the proposed roles of the receptor which include anxiety, pain perception, gastric acid secretion, and growth and differentiation of the gastric mucosa1,2.

ID gène: 12426

NCBI Accession: NM_176875

UniProt: P56481

Pathways: Positive Regulation of Peptide Hormone Secretion, Feeding Behaviour