Cortactin anticorps (Intracellular)

N° du produit ABIN7043085

Cet anticorps anti-Cortactin Polyclonal Lapin (ABIN7043085) détecte spécifiquement Cortactin dans WB et IHC. L’anticorps est réactif avec des échantillons de Souris.

Aperçu rapide pour Cortactin anticorps (Intracellular) (ABIN7043085)

Antigène: Cortactin (CTTN)

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cortactin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Cortactin anticorps

Épitope: AA 346-359, Intracellular

Fonction: A Rabbit Polyclonal Antibody to Cortactin

Réactivité croisée: Humain, Souris, Rat

Homologie: Rat,human - identical

Attributs du produit: Anti-Cortactin Antibody (ABIN7043085, ABIN7045162 and ABIN7045163) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot analysis. It has been designed to recognize Cortactin from rat, mouse, and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)KTSNIRANFENLAK, corresponding to amino acid residues 346 - 359 of mouse Cortactin

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200-1:1000

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:300

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235169)

Blocking Peptide: (ABIN7235169)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Cortactin

Antigène: Cortactin (CTTN)

Autre désignation: CTTN

Sujet:

Synonyms: Src substrate cortactin, Oncogene EMS1, EMS1, Amplaxin, CTTN

Description: Cortical acting binding protein, Cortactin, is an actin-binding protein involved in cytoskeletal regulation1. Cortactin is a 63-65 kDa protein that consists of four major domains: N-terminal acidic (NTA), 6.5 tandems repeat, proline-rich domain, and the C-terminal Src homology 3 domains (SH3 domains)2 and it is regulated by post translational modifications such as phosphorylation and acetylation1.The actin filament network provides mechanical support as well as protrusive and contractile forces essential for directed cell motility and cell and tissue morphogenesis. Cortactin activates the Arp2/3 complex, the main regulator of actin polymerization, and thereby regulates the assembly of branched actin3.Overexpression of cortactin was shown to enhance cell migration, invasion, and tumor cell metastasis. It is also overexpressed in various types of cancer such as breast cancers as well as head and neck tumors1.

ID gène: 13043

NCBI Accession: NM_138565

UniProt: Q60598

Pathways: Signalisation MAPK