GFRA1 anticorps (Extracellular Domain)

N° du produit ABIN7043211

Cet anticorps anti-GFRA1 Polyclonal Lapin (ABIN7043211) détecte spécifiquement GFRA1 dans WB, IHC, IF, IC et LCI. L’anticorps est réactif avec des échantillons de Rat.

Aperçu rapide pour GFRA1 anticorps (Extracellular Domain) (ABIN7043211)

Antigène: GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GFRA1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC), Live Cell Imaging (LCI)

Détail du produit anti-GFRA1 anticorps

Épitope: AA 72-83, Extracellular Domain

Fonction: A Rabbit Polyclonal Antibody to GDNF Family Receptor α1

Réactivité croisée: Humain, Souris, Rat

Homologie: Mouse,human - identical

Attributs du produit: Anti-GFR alpha 1 (extracellular) Antibody is directed against an extracellular epitope of rat GDNF receptor α1. Anti-GFR alpha 1 (extracellular) Antibody (ABIN7043211, ABIN7044777 and ABIN7044778) can be used in western blot, immunohistochemistry, immunocytochemistry and live cell imaging applications. It has been designed to recognize GFR α1 from mouse, rat and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: CRSAMEALKQKS, corresponding to amino acid residues 72-83 of rat GFRA1

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: 1:50

IHC: 1:100

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235577)

Blocking Peptide: (ABIN7235577)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur GFRA1

Antigène: GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))

Autre désignation: GFRA1

Sujet:

Synonyms: GFRA1, GFRα1, GDNF family receptor α1, GDNF receptor alpha 1, Ret ligand 1, RETL1, TRNR1

Description: The GDNF family ligands (GFLs) belong to the super family of the TGF-β. They belong to the group of cystine-knot protein and function as homodimers1. This family includes glial cell line-derived neurotrophic factor (GDNF), artemin (ARTN), Neurturin (NRTN) and persephin (PSPN)2.These factors are heavily involved in the development and function of the nervous system (both central and peripheral). In particular GDNF has an important role outside the nervous system where it plays a role in kidney morphogenesis1.In general GFLs all signal through a signal through the receptor tyrosine kinase Ret. Their specificity is implemented by different GDNF family receptor a (GFRα), which act as co-receptors. These extracellular proteins are bound to the plasma membrane via a glycosyl phosphatidyl inositol (GPI) anchor. GFRα1-4 are responsible for the binding of GDNF, NRTN, ARTN, and PSPN respectively and the subsequent activation of Ret. Soluble forms of the receptor by the cleavage of a yet unknown phospholipase or protease can be detected1,3. Also alternative spliced forms of the protein can lead to soluble forms of GFRα receptors3. In respect to their important role in development, individual knockout of either gdnf, gfra1 or ret gives rise to lethal phenotypes2.

ID gène: 25454

NCBI Accession: NM_145793

UniProt: Q62997