HRH3 anticorps (3rd Intracellular Loop)

N° du produit ABIN7886504

Cet anticorps anti-HRH3 Polyclonal Lapin (ABIN7886504) détecte spécifiquement HRH3 dans WB, IHC, IF et IC. L’anticorps est réactif avec des échantillons de Rat.

Aperçu rapide pour HRH3 anticorps (3rd Intracellular Loop) (ABIN7886504)

Antigène: HRH3 (Histamine Receptor H3 (HRH3))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HRH3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC)

Détail du produit anti-HRH3 anticorps

Épitope: 3rd Intracellular Loop

Fonction: A Rabbit Polyclonal Antibody to Histamine H3 Receptor

Réactivité croisée: Souris, Rat

Homologie: Mouse - identical, human 14,16 amino acid residues identical

Attributs du produit: Anti-Histamine H3 Receptor (HRH3) Antibody is directed against an epitope of the rat histamine H3 receptor. Anti-Histamine H3 Receptor (HRH3) Antibody (ABIN7043271 and ABIN7044509) can be used in western blot, immunocytochemistry and immunohistochemistry applications. It has been designed to recognize H3R from rat, mouse and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)RTRLRLDGGREAGPE, corresponding to amino acids 228-242 of rat HRH3 

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:100

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235758)

Blocking Peptide: (ABIN7235758)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur HRH3

Antigène: HRH3 (Histamine Receptor H3 (HRH3))

Autre désignation: HRH3

Sujet:

Synonyms: H3R, HH3R, GPCR97

Description: Histamine (2-[4-imidazole]ethylamine) is a low-molecular-weight amine synthesized from L-histidine. It is produced by various cells throughout the body, including central nervous system neurons, gastric mucosa parietal cells, mast cells, basophils and lymphocytes. Histamine is a major biological mediator whose functions include, among many others, regulation of vascular smooth muscle, immune regulation, regulation of sleep-wake cycles and regulation of gastric acid secretion.1The biological effects of histamine are mediated through four receptors (H1-H4 receptors) all of which belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily.H3 receptor couples to Gi/G0 proteins and receptor activation leads to inhibition of adenylate cyclase, activation of the mitogen-activated protein kinase (MAPK) cascade and inhibition of the Na+/H+ exchanger.1,2H3 receptors are expressed primarily in the central nervous system (CNS) where they are located in presynaptic membranes of histaminergic neurons, where they negatively regulate the synthesis and release of histamine. In addition, H3 receptors are also located on nonhistaminergic neurons, where they regulate the release of other amines such as dopamine, serotonin, and norepinephrine.2,3Based on these studies, a central role for H3 receptors has been proposed in disorders involving cognition such as attention deficit and hyperactivity disorder (ADHD), Alzheimer disease and Schizophrenia, as well as sleep and energy homeostasis (i.e. obesity) disorders.2,3

ID gène: 85268

NCBI Accession: NM_007232

UniProt: Q9QYN8

Pathways: cAMP Metabolic Process, Feeding Behaviour