NGFR anticorps (Intracellular, Juxtamembrane Domain)

N° du produit ABIN7886733

L’anticorps anti-NGFR Polyclonal Lapin est utilisé pour la détection de NGFR dans des échantillons de Humain. Il a été validé pour WB, IHC et IF.

Aperçu rapide pour NGFR anticorps (Intracellular, Juxtamembrane Domain) (ABIN7886733)

Antigène: NGFR (Nerve Growth Factor Receptor (NGFR))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NGFR est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-NGFR anticorps

Épitope: AA 278-293, Intracellular, Juxtamembrane Domain

Fonction: A Rabbit Polyclonal Antibody to Human Neurotrophin Receptor p75NTR

Réactivité croisée: Humain, Souris, Rat

Homologie: Mouse,rat - identical

Attributs du produit: Anti-p75 NGF Receptor (intracellular) Antibody is directed against an epitope of human p75NTR. Anti-p75 NGF Receptor (intracellular) Antibody (ABIN7043348, ABIN7044763 and ABIN7044764) can be used in western blot and immunohistochemistry applications. It has been designed to recognize p75NTR from human, mouse and rat samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: CKQNKQGANSRPVNQT corresponding to amino acid residues 278-293 of human p75NTR 

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Commentaires:

Cited Application: IP|IHC

Negative Control: (ABIN7236006)

Blocking Peptide: (ABIN7236006)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur NGFR

Antigène: NGFR (Nerve Growth Factor Receptor (NGFR))

Autre désignation: NGFR

Sujet:

Synonyms: p75NTR, p75 Neurotrophin receptor, Low affinity NGF receptor, TNFR superfamily member 16, TNFRSF16, CD271

Description: The p75 neurotrophin receptor (p75NTR) is a member of the TNF receptor superfamily. p75NTR, like all the superfamily members is a type I transmembrane protein with tandem cysteine-rich domains in the extracellular portion and a intracellular death domain. p75NTR binds its ligands as a homodimer but can also form heterodimers with other receptors such as TrkA, TrkB, TrkC, Nogo receptor and sortilin. The precise multimeric receptor complex formed between p75NTR and the other receptors will determine the ligand being recognized (see below) and the biological response to its binding.As it name implies, p75NTR binds all the neurotrophins (NGF, BDNF, NT-3 and NT-4) with similar nM affinities. Co-expression of p75NTR with the Trk receptors enhances the ability to bind and respond to the specific neurotrophin and induces cell survival. On the other hand, it has recently been demonstrated that p75NTR binds with high affinity to the unprocessed form of NGF (proNGF) probably as a complex with sortilin and this leads to cell death by apoptosis. Finally, a multimeric complex of p75NTR and Nogo receptor binds myelin proteins such as Nogo-66, MAG and OmgP resulting in inhibition of axonal growth.

ID gène: 4804

NCBI Accession: NM_002507

UniProt: P08138

Pathways: Signalisation NF-kappaB, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding