Neuregulin 2 anticorps (Extracellular, N-Term)

N° du produit ABIN7043355

Cet anticorps anti-Neuregulin 2 Polyclonal Lapin (ABIN7043355) détecte spécifiquement Neuregulin 2 dans WB, IHC et IF. L’anticorps est réactif avec des échantillons de Rat.

Aperçu rapide pour Neuregulin 2 anticorps (Extracellular, N-Term) (ABIN7043355)

Antigène: Neuregulin 2 (NRG2)

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Neuregulin 2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-Neuregulin 2 anticorps

Épitope: AA 297-311, Extracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to Neuregulin-2

Réactivité croisée: Souris, Rat

Homologie: Mouse,human - identical

Attributs du produit: Anti-NRG2 (extracellular) Antibody (ABIN7043355, ABIN7044720 and ABIN7044721) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize Neuregulin-2 from rat, mouse, and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)RDIRIKYGNGRKNSR, corresponding to amino acid residues 297-311 of rat Neuregulin-2

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:300

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7236030)

Blocking Peptide: (ABIN7236030)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Neuregulin 2

Antigène: Neuregulin 2 (NRG2)

Autre désignation: NRG2

Sujet:

Synonyms: Neuregulin-2, Pro-neuregulin-2 membrane-bound isoform, Pro-NRG2, Neural- and thymus-derived activator for ErbB kinases, NTAK

Description: Neuregulins (NRGs) are a multi member protein family involved in cell to cell communication. This family includes four human neuregulin paralogs NRG1-NRG4 which produce multiple isoforms through alternative splicing.NRGs are involved in several physiological processes including heart and peripheral nervous system development. They act in part by binding to the extracellular region of ErbB/HER transmembrane tyrosine kinases, leading to receptor dimerization and ultimately to the activation of a complex network of downstream signaling events1,2.NRG2 transcript levels markedly increase following birth, suggesting that NRG2 has important functions in the postnatal and adult brain. Several studies have also shown that NRG2 modulates glutamatergic transmission in GABAergic neurons and selectively affects GluN2B-containing NMDA receptors2,3.The region containing the NRG2 locus is associated with schizophrenia and other psychiatric disorders and genetically linked to ADHD in genome-wide scans2.

ID gène: 432361

NCBI Accession: NM_013982

UniProt: O35569

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway