Neuregulin 3 anticorps (Extracellular, N-Term)

N° du produit ABIN7043356

Cet anticorps Lapin Polyclonal détecte spécifiquement Neuregulin 3 dans WB. Il présente une réactivité avec des échantillons de Souris.

Aperçu rapide pour Neuregulin 3 anticorps (Extracellular, N-Term) (ABIN7043356)

Antigène: Neuregulin 3 (NRG3)

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Neuregulin 3 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Neuregulin 3 anticorps

Épitope: AA 167-180, Extracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to Neuregulin-3

Réactivité croisée: Humain, Souris, Rat

Homologie: Human,rat - identical

Attributs du produit: Anti-NRG3 (extracellular) Antibody (ABIN7043356, ABIN7044722 and ABIN7044723) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot analysis. It has been designed to recognize Neuregulin-3 from rat, mouse, and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)RFPGHRVPIRASPR, corresponding to amino acid residues 167-180 of mouse Neuregulin-3

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7236034)

Blocking Peptide: (ABIN7236034)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Neuregulin 3

Antigène: Neuregulin 3 (NRG3)

Autre désignation: NRG3

Sujet:

Synonyms: Neuregulin-3, HRG3

Description: Neuregulins (NRGs) are single-pass membrane proteins belonging to a multi member family of epidermal growth factor (EGF)-like signaling molecules involved in cell-cell communication. This family includes four human neuregulin paralogs NRG1-NRG4 with multiple isoforms through alternative splicing1.Neuregulin 3 (NRG3) plays a key role in the embryonic cerebral cortex development by regulating the migration and patterning of neural progenitor cells. It specifically binds to the ErbB4 receptor tyrosine kinase in the developing mammalian forebrain2,3.Neuregulin 3 is almost exclusively expressed in the nervous system with highest expression in the anterior cingulate and frontal cortex3,4.Mutations in the neuregulin 3 gene are linked to different mental disorders accompanied with cognitive and behavioral abnormalities such as developmental delay, cognitive impairment, and psychiatric illness2,3. Single nucleotide polymorphisms are associated with delusions in patients with schizophrenia and linked to the disease itself. Knockout mice display novelty-induced hyperactivity and are deficient fear conditioning4.

ID gène: 18183

NCBI Accession: NM_001010848

UniProt: O35181

Pathways: Signalisation RTK