Neurotrophin 3 anticorps (Intracellular)

N° du produit ABIN7886722

Cet anticorps Lapin Polyclonal détecte spécifiquement Neurotrophin 3 dans WB, IHC et IF. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Neurotrophin 3 anticorps (Intracellular) (ABIN7886722)

Antigène: Neurotrophin 3 (NTF3)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Neurotrophin 3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-Neurotrophin 3 anticorps

Épitope: AA 39-48, AA 177-186, Intracellular

Fonction: A Rabbit Polyclonal Antibody to Neurotrophin 3

Réactivité croisée: Humain, Souris, Rat

Homologie: Rat,mouse,chicken,Xenopus - identical, cat - 9,10 amino acid residues identical

Attributs du produit: Anti-Neurotrophin 3 Antibody is directed against an epitope of human Neurotrophin 3. Anti-Neurotrophin 3 Antibody (ABIN7043392, ABIN7044748 and ABIN7044749) can be used in western blot and immunohistochemical applications. It has been designed to recognize from rat, mouse and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: GEIKTGNSPV(C), corresponding to amino acid residues 39-48 of mature human NT-3 (residues 177-186 of the NT-3 precursor)

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:300

IP: The optimal concentration should be determined by the user

Commentaires:

Cited Application: IP|IHC

Negative Control: (ABIN7236144)

Blocking Peptide: (ABIN7236144)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Neurotrophin 3

Antigène: Neurotrophin 3 (NTF3)

Autre désignation: NTF3

Sujet:

Synonyms: NTF3, Nerve growth factor 2, NGF2, HDNF

Description: The neurotrophins ("neuro" meaning nerve and "trophe" meaning nutrient) are a family of soluble, basic growth factors which regulate neuronal development, maintenance, survival and death in the CNS and PNS.1 The structural hallmark of all neurotrophins is the characteristic arrangement of the disulfide bridges, known as the cysteine knot, which has been found in other growth factors such as PDGF.2 The rat and human forms of neurotrophin-3 (NT-3) are 96 % homologous. NT-3 has been shown to strengthen synaptic connections to motoneurons in the neonatal rat,3 to serve as an anti-inflammatory factor, to suppress microglial activation,4 to play a critical role in regulating T helper 1/T helper 2 cell balance5 and to modify potassium currents in isolated inner hair cells from guinea pig cochlea.6 The biological effects of NT-3 are mediated by two receptors: TrkC, which is specific for NT-3, and p75NTR, which binds all the neurotrophins.7

ID gène: 4908

NCBI Accession: NM_001102654

UniProt: P20783

Pathways: Signalisation RTK, Neurotrophin Signaling Pathway