TMEM38A anticorps (C-Term, Intracellular)

N° du produit ABIN7043861

L’anticorps anti-TMEM38A Polyclonal Lapin est utilisé pour la détection de TMEM38A dans des échantillons de Rat. Il a été validé pour WB, IHC et IC.

Aperçu rapide pour TMEM38A anticorps (C-Term, Intracellular) (ABIN7043861)

Antigène: TMEM38A (Transmembrane Protein 38A (TMEM38A))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TMEM38A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunochromatography (IC)

Détail du produit anti-TMEM38A anticorps

Épitope: AA 259-274, C-Term, Intracellular

Fonction: A Rabbit Polyclonal Antibody to TRIC-A Channel

Réactivité croisée: Souris, Rat

Homologie: Mouse - identical, human - will not recognize human TRIC-A

Attributs du produit: Anti-TRIC-A (TMEM38A) Antibody (ABIN7043861 and ABIN7045315) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, immunohistochemistry, and immunocytochemistry applications. It has been designed to recognize TRIC-A from rat and mouse samples. The antibody is not suited to recognize TRIC-A from human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)DNHGAPHGMGLGTQHS, corresponding to amino acid residues 259-274 of rat TRIC-A

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: 1:200

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Cited Application: IHC

Negative Control: (ABIN7237521)

Blocking Peptide: (ABIN7237521)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur TMEM38A

Antigène: TMEM38A (Transmembrane Protein 38A (TMEM38A))

Autre désignation: TMEM38A

Sujet:

Synonyms: Trimeric intracellular cation channel type A, 27 kDa sarcoplasmic reticulum protein, Transmembrane protein 38A

Description: Intracellular Ca2+ levels are important in proper cellular functions and have prominent roles in various cell signaling pathways and are crucial for muscle contractions. Indeed, an important step leading to muscle contraction is the massive release of Ca2+ ions from the endoplasmic/sarcoplasmic reticulum (ER/SR) to the cytosol. A battery of results suggest that specific K+ channels are important to counteract the Ca2+ outflow in order to neutralize the negative potential created by the movement of Ca2+ ions. It is believed that TRIC channels are responsible for neutralizing this negative potential1,2.Trimeric intracellular cation-specific (TRIC) channels are critical for proper management of intracellular stores. TRIC-A and TRIC-B both belong to this family and are both permeable to monovalent ions with a preference for K+ 3. Both channels are localized to the ER/SR membrane. Each TRIC subunit contains three transmembrane domains, a cytoplasmic C-terminus and a luminal N-terminus. Functional entities are formed by homotrimerizarion4. The activity of TRIC-A is regulated by voltage whereas that of TRIC-B can be regulated by different mechanisms3.Knockout studies of these channels have shown that TRIC-A knockout mice are viable while those of TRIC-B die at the neonatal stage5.TRIC-A is mostly expressed in excitable tissues like the brain and muscle while TRIC-B is ubiquitously expressed.

ID gène: 306327

NCBI Accession: NM_024074

UniProt: A6ZIQ8