TMEM38A anticorps (C-Term, Intracellular)

N° du produit ABIN7885621

L’anticorps anti-TMEM38A Polyclonal Lapin est utilisé pour la détection de TMEM38A dans des échantillons de Rat et Souris. Il a été validé pour WB, IHC et IC.

Aperçu rapide pour TMEM38A anticorps (C-Term, Intracellular) (ABIN7885621)

Antigène: TMEM38A (Transmembrane Protein 38A (TMEM38A))

Reactivité: Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TMEM38A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunochromatography (IC)

Classe de qualité: Carrier-free

Détail du produit anti-TMEM38A anticorps

Épitope: AA 259-274, C-Term, Intracellular

Fonction: A Rabbit Polyclonal Antibody to TRIC-A Channel

Homologie: Mouse - identical, human - will not recognize human TRIC-A

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)DNHGAPHGMGLGTQHS, corresponding to amino acid residues 259-274 of rat TRIC-A

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: 1:200

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7237521)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur TMEM38A

Antigène: TMEM38A (Transmembrane Protein 38A (TMEM38A))

Autre désignation: Trimeric intracellular cation channel type A

Sujet:

Synonyms: Trimeric intracellular cation channel type A, 27 kDa sarcoplasmic reticulum protein, Transmembrane protein 38A

Description: Intracellular Ca2+ levels are important in proper cellular functions and have prominent roles in various cell signaling pathways and are crucial for muscle contractions. Indeed, an important step leading to muscle contraction is the massive release of Ca2+ ions from the endoplasmic/sarcoplasmic reticulum (ER/SR) to the cytosol. A battery of results suggest that specific K+ channels are important to counteract the Ca2+ outflow in order to neutralize the negative potential created by the movement of Ca2+ ions. It is believed that TRIC channels are responsible for neutralizing this negative potential1,2.Trimeric intracellular cation-specific (TRIC) channels are critical for proper management of intracellular stores. TRIC-A and TRIC-B both belong to this family and are both permeable to monovalent ions with a preference for K+ 3. Both channels are localized to the ER/SR membrane. Each TRIC subunit contains three transmembrane domains, a cytoplasmic C-terminus and a luminal N-terminus. Functional entities are formed by homotrimerizarion4. The activity of TRIC-A is regulated by voltage whereas that of TRIC-B can be regulated by different mechanisms3.Knockout studies of these channels have shown that TRIC-A knockout mice are viable while those of TRIC-B die at the neonatal stage5.TRIC-A is mostly expressed in excitable tissues like the brain and muscle while TRIC-B is ubiquitously expressed.

ID gène: 306327

UniProt: A6ZIQ8