Recombinant BACE2 anticorps

N° du produit ABIN7072331

L’anticorps Souris Monoclonal anti-BACE2 a été validé pour WB et IHC. Il convient pour détecter BACE2 dans des échantillons de Humain.

Aperçu rapide pour Recombinant BACE2 anticorps (ABIN7072331)

Antigène: BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BACE2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: 1-9

Détail du produit anti-BACE2 anticorps

Fonction: Anti-BACE2 [1/ 9 ], Mouse IgG1, kappa

Attributs du produit:

Original Species of Ab: Mouse

Original Format of Ab: IgG

Purification: Protein A affinity purified

Immunogène: Human BACE2 244-333.

Isotype: IgG1 kappa

Information d'application

Indications d'application: The antibody binds specifically to BACE2, an enzyme responsible for the proteolytic cleavage of amyloid precursor protein (APP). The protein is cleaved between residues 690 and 691, leading to the formation of beta-cleaved soluble APP and a C-terminal membrane bound fragment (CTFβ). The latter is then cleaved by gamma-secretase to generate amyloid beta peptide. BACE is the rate-limiting enzyme in the pathway, and is a potential target in the treatment of Alzheimer's Disease (AD),a neurodegenerative disorder characterised by amyloid beta plaques within the brain. The BACE2 protein is encoded in chromosome 21, in a region critical for the development of Down's Syndrome, and may play a role in the amyloid beta deposition in the disease.

Commentaires:

This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur BACE2

Antigène: BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))

Autre désignation: BACE2

Sujet: Beta-secretase 2, Aspartic-like protease, Aspartyl protease 1, Asp1, Beta-site amyloid precursor protein cleaving enzyme 2, Down syndrome aspartic protease, DRAP, Memapsin-1, Membrane-associated aspartic protease 1, theta-secretase

UniProt: Q9Y5Z0