Recombinant ITGAL anticorps

N° du produit ABIN7072545

Cet anticorps anti-ITGAL est un anticorps Lapin Chimeric détectant ITGAL dans InhA. Adapté pour Humain.

Aperçu rapide pour Recombinant ITGAL anticorps (ABIN7072545)

Antigène: ITGAL (Integrin alpha-L (ITGAL))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Chimeric

Conjugué: Cet anticorp ITGAL est non-conjugé

Application: Inhibition Assay (InhA)

Clone: MHM24

Détail du produit anti-ITGAL anticorps

Fonction: Anti-CD11a [MHM24], Rabbit IgG, kappa

Specificité: MHM24 binds to the CD11a subunit of lymphocyte function-associated antigen. It binds to both the high- and low-affinity forms of the antigen.

Attributs du produit:

Original Species of Ab: Mouse

Original Format of Ab: IgG

Purification: Protein A affinity purified

Immunogène: Spleen cells from BALB/c mice immunised with EBV-transformed human lymphoblastoid cells were fused with P3-NSUlAg4.1 myeloma cells and the resulting hybridomas were screened for antibody production by a radioimmunoassay on T and B cell lines.

Isotype: IgG kappa

Information d'application

Indications d'application: Cytofluorography was used to show the binding of MHM24 to peripheral blood lymphocytes, with 97.3 % of cells stained by MHM24 (Hildreth et al, 1983). In inhibition experiments, MHM24 inhibited T cell-mediated lysis of virus-infected cells (Hildreth et al, 1983). Additionally, MHM24 inhibited NK cell-mediated lysis (Hildreth et al, 1983).Flow cytometry showed MHM24 exhibits non-selective binding to high-affinity and low-affinity forms of LFA-1 (Huang et al, 2006). Murine MHM24 was humanised and shown to prevent adhesion of human T cells to human keratinocytes and the proliferation of T cells in response to nonautologous leukocytes (Werther et al, 1996).

Commentaires:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur ITGAL

Antigène: ITGAL (Integrin alpha-L (ITGAL))

Autre désignation: CD11a

Sujet: Integrin alpha-L, CD11 antigen-like family member A, leukocyte function-associated molecule 1 alpha chain, human lymphocyte function antigen

UniProt: P20701

Pathways: Activated T Cell Proliferation, Integrin Complex