Recombinant CD80 anticorps

N° du produit ABIN7072690

Cet anticorps Lapin Chimeric détecte spécifiquement CD80 dans ELISA et BR. Il présente une réactivité envers Humain.

Aperçu rapide pour Recombinant CD80 anticorps (ABIN7072690)

Antigène: CD80

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Chimeric

Conjugué: Cet anticorp CD80 est non-conjugé

Application: ELISA, Blocking Reagent (BR)

Clone: 16C10

Détail du produit anti-CD80 anticorps

Fonction: Anti-CD80 [16C10], Rabbit IgG, lambda

Specificité: This antibody binds human CD80 and inhibits the B7.1:CD28 pathway.

Attributs du produit:

Original Species of Ab: Rhesus Macaque

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogène: This antibody was generated by immunization of cynomolgus monkeys with human B7.1 antigen.

Isotype: IgG lambda

Information d'application

Indications d'application: This antibody can be used for identification of human B7.1 antigen and is capable of inhibiting the binding of B7.1 to CD28, however it does not block the binding of B7.1 to CTLA-4. This antibody further inhibits the production of IL-2. Blocking of the primary activation signal between CD28 and B7.1 (CD80) with these antibodies while allowing the unimpaired or coincident interaction of CTLA-4 and B7.1 represents a combined antagonistic effect on positive co-stimulation with an agonistic effect on negative signaling. The binding of the antibody to soluble B7.1 was tested using ELISA. This antibody tested positive for binding to human C1q protein. This antibody is reported to cause keratinocyte hyperproliferation and decrease in psoriasis by inhibiting the B7:CD28 pathway. This antibody is further reported to be useful for the treatment of intestinal inflammation and rheumatoid arthritis.

Commentaires:

This chimeric rabbit antibody was made using the variable domain sequences of the original IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur CD80

Antigène: CD80

Autre désignation: CD80

Sujet: B7.1, CD28L, CD28LG, B7-1, B7, BB1, B7/BB1,T-lymphocyte activation antigen CD80, Activation B7-1 antigen, CTLA-4 counter-receptor B7.1, CTLA4L, CTLA-4L

UniProt: P33681

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints