Recombinant Mesothelin anticorps

N° du produit ABIN7072729

Cet anticorps Souris Monoclonal détecte spécifiquement Mesothelin dans ELISA, FACS et IP. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Recombinant Mesothelin anticorps (ABIN7072729)

Antigène: Mesothelin (MSLN)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Mesothelin est non-conjugé

Application: ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP)

Clone: 11-25

Détail du produit anti-Mesothelin anticorps

Fonction: Anti-Mesothelin [11-25], Mouse IgG2b, kappa

Specificité:

This antibody binds the human mesothelin protein, which is highly expressed in many human cancers, including the majority of pancreatic adenocarcinomas, ovarian cancers, and mesotheliomas.

Application Notes original Clone: It is recommended that this antibody be used in combination with mAb IC14-30 to detect mesothelin with high sensitivity in a capture ELISA. This antibody can also immunoprecipitate recombinant mesothelin. NCI-H226 and NCI-H520 were incubated with anti-MSLN antibodies (11-25) or an isotype-matched control antibody and followed by PE-conjugate anti-mouse IgG. Antigen expression was detected by flow cytometry (Iwahori et al., 2008, PMID: 18394747). ⁶⁴Cu labeled 11-25 was used in vitro cell binding assay and in vivo positron emission tomography (PET) imaging in the tumor-bearing mice (Kobayashi et al., 2015, PMID: 25883990).

Purification: Protein A affinity purified

Immunogène: The original antibody was generated by immunizing BALB/c mice with the purified recombinant mesothelin protein.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

OriginalSpeciesName: Mouse

OriginalFormat: IgG2b

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur Mesothelin

Antigène: Mesothelin (MSLN)

Autre désignation: Mesothelin

Sujet: MSLN, CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor

UniProt: Q13421

Pathways: EGFR Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process