CUBN anticorps

N° du produit ABIN7073601

L’anticorps anti-CUBN Polyclonal produit chez le Lapin a été validé pour WB, IHC et IF. Il convient pour la détection de CUBN dans des échantillons provenant de Humain, Rat et Souris. }

Aperçu rapide pour CUBN anticorps (ABIN7073601)

Antigène: CUBN (Cubilin (Intrinsic Factor-Cobalamin Receptor) (CUBN))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CUBN est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-CUBN anticorps

Réactivité croisée: Humain, Rat

Purification: Affinity purification

Immunogène: Recombinant protein corresponding to Mouse Cubilin

Information d'application

Indications d'application: WB (M,R) 1:500-1:1000, IHC/IF (H,M,R) 1:650-1:1300

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur CUBN

Antigène: CUBN (Cubilin (Intrinsic Factor-Cobalamin Receptor) (CUBN))

Autre désignation: Cubilin

Sujet: Cubilin is an endocytic receptor that lacks a classical transmembrane region. It is a multidomain receptor that contains an amino terminal 110 residue segment followed by 8 epidermal growth factor (EGF)-like repeats and a contiguous stretch of 27 CUB domains. Cubilin acts as a receptor for intrinsic factor-vitamin B12 complexes. Cubilin is located within the epithelium of intestine and kidney. Mutations in Cubilin may play a role in autosomal recessive megaloblastic anemia also known as Imerslund-Grasbeck's disease, which causes intestinal malabsorption of vitamin B12.

Poids moléculaire: 399 kDa

ID gène: 65969

NCBI Accession: NP_001074553

UniProt: Q9JLB4

Pathways: Metabolism of Steroid Hormones and Vitamin D, Lipid Metabolism