GDF5 anticorps

N° du produit ABIN7074131

Cet anticorps Lapin Polyclonal détecte spécifiquement GDF5 dans WB, IHC et IF. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour GDF5 anticorps (ABIN7074131)

Antigène: GDF5 (Growth Differentiation Factor 5 (GDF5))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GDF5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-GDF5 anticorps

Réactivité croisée: Humain, Rat

Purification: Affinity purification

Immunogène: KLH conjugated Synthetic peptide corresponding to Mouse GDF 5

Information d'application

Indications d'application: WB (H,M) 1:500-1:1000, IHC/IF (H,R) 1:200-1:400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur GDF5

Antigène: GDF5 (Growth Differentiation Factor 5 (GDF5))

Autre désignation: GDF 5

Sujet: Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction . Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG . Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 .

Poids moléculaire: 55 kDa

ID gène: 14563

NCBI Accession: NP_032135

UniProt: P43027