Verified
SUV39H2
Reactivité: Rat
WB, ELISA
Hôte: Chèvre
Polyclonal
unconjugated
Indications d'application
IHC/IF (H,M,R) 1:1000-1:4000/1:500-1:3000
Restrictions
For Research Use only
Format
Liquid
Buffer
PBS, pH 7.4, 0.02 % sodium azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
-20 °C
Antigène
SUV39H2
(Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2))
Autre désignation
KMT1B/SUV39H2
Sujet
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats.