RBX1 anticorps (AA 1-108)

N° du produit ABIN7091652

Cet anticorps Souris Monoclonal détecte spécifiquement RBX1 dans WB. Il présente une réactivité envers Humain.

Aperçu rapide pour RBX1 anticorps (AA 1-108) (ABIN7091652)

Antigène: RBX1 (Ring-Box 1, E3 Ubiquitin Protein Ligase (RBX1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp RBX1 est non-conjugé

Application: Western Blotting (WB)

Clone: C8F22

Détail du produit anti-RBX1 anticorps

Épitope: AA 1-108

Homologie: Human,Mouse

Immunogène: Recombinant human RBX1 between 1-108 amino acids.

Information d'application

Indications d'application: WB 1:300-5000

Restrictions: For Research Use only

Stockage

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur RBX1

Antigène: RBX1 (Ring-Box 1, E3 Ubiquitin Protein Ligase (RBX1))

Autre désignation: RBX1

Sujet:

Synonyms: E3 ubiquitin-protein ligase RBX1, MGC13357, MGC1481, Protein ZYP, Rbx 1, Rbx1, RBX1_HUMAN, Regulator of Cullins 1, Ring box 1, RING box protein 1, RING finger protein 75, RING finger protein, RING-box protein 1, Ringbox protein 1, RNF 75, RNF75, ROC 1, ROC1, ZYP protein.

Background: E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41.

ID gène: 9978

UniProt: P62877

Pathways: Cycle Cellulaire, M Phase, SARS-CoV-2 Protein Interactome