CD33 anticorps (AA 18-269)

N° du produit ABIN7092878

Cet anticorps anti-CD33 est un anticorps Lapin Monoclonal détectant CD33 dans FACS et ELISA. Adapté pour Humain.

Aperçu rapide pour CD33 anticorps (AA 18-269) (ABIN7092878)

Antigène: CD33

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp CD33 est non-conjugé

Application: Flow Cytometry (FACS), ELISA

Clone: DM77

Détail du produit anti-CD33 anticorps

Épitope: AA 18-269

Purification: Purified from cell culture supernatant by affinity chromatography

Immunogène: Recombinant human CD33 (Asp18-His269) (ABIN6961110) produced by using human HEK293 cells

Isotype: IgG

Information d'application

Indications d'application: ELISA 1/5000-10000,Flow Cyt  1/100

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute with deionized water

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.,0.1 % Procline 300

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détails sur CD33

Antigène: CD33

Autre désignation: CD33

Sujet: Synonyms:CD33,SIGLEC3,gp67
Description:Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans. Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK. These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules. One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K.

Poids moléculaire: 39.8kDa

ID gène: 945

UniProt: P20138