IL-6 Receptor anticorps (AA 20-365)

N° du produit ABIN7092952

L’anticorps anti-IL-6 Receptor Monoclonal Lapin est utilisé pour la détection de IL-6 Receptor dans des échantillons de Humain. Il a été validé pour ELISA et FACS.

Aperçu rapide pour IL-6 Receptor anticorps (AA 20-365) (ABIN7092952)

Antigène: IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp IL-6 Receptor est non-conjugé

Application: ELISA, Flow Cytometry (FACS)

Clone: DM152

Détail du produit anti-IL-6 Receptor anticorps

Épitope: AA 20-365

Fonction: Anti-IL6R antibody(DM152), Rabbit mAb

Purification: Purified from cell culture supernatant by affinity chromatography

Immunogène: Recombinant human IL6R(Leu20-Pro365) (ABIN6964085) produced by using human HEK293 cells

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:5000-10000, Flow Cyt 1:100

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please see Certificate of Analysis for specific instructions of reconstitution.

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détails sur IL-6 Receptor

Antigène: IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))

Autre désignation: IL6R

Sujet: Synonyms:CD126, gp80, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ
Description:This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.

Poids moléculaire: 51.5KDa

UniProt: P08887

Pathways: Signalistation JAK/STAT, Autophagy, Growth Factor Binding, Cancer Immune Checkpoints