ATF6 anticorps

N° du produit ABIN7111246

Cet anticorps Lapin Polyclonal détecte spécifiquement ATF6 dans WB, IHC, ELISA, IP et IF. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour ATF6 anticorps (ABIN7111246)

Antigène: ATF6 (Activating Transcription Factor 6 (ATF6))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATF6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF)

Détail du produit anti-ATF6 anticorps

Fonction: ATF6 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: activating transcription factor 6

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:10-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur ATF6

Antigène: ATF6 (Activating Transcription Factor 6 (ATF6))

Autre désignation: ATF6

Sujet:

Synonyms: Cyclic AMP-dependent transcription factor ATF-6 alpha (cAMP-dependent transcription factor ATF-6 alpha)|Activating transcription factor 6 alpha (ATF6-alpha)|Processed cyclic AMP-dependent transcription factor ATF-6 alpha|ATF6

Background: Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response(UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element(ERSE)(5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II(5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.

Poids moléculaire: 90 kDa

ID gène: 22926

UniProt: P18850

Pathways: ER-Nucleus Signaling, Unfolded Protein Response