AP2A2 anticorps

N° du produit ABIN7111308

Cet anticorps anti-AP2A2 est un anticorps Lapin Polyclonal détectant AP2A2 dans WB, IHC et ELISA. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour AP2A2 anticorps (ABIN7111308)

Antigène: AP2A2 (Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AP2A2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-AP2A2 anticorps

Fonction: AP2A2 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: adaptor-related protein complex 2, alpha 2 subunit

Isotype: IgG

Information d'application

Indications d'application: WB: 1:200-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur AP2A2

Antigène: AP2A2 (Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2))

Autre désignation: AP2A2

Sujet:

Synonyms: AP-2 complex subunit alpha-2|100 kDa coated vesicle protein C|Adaptor protein complex AP-2 subunit alpha-2|Adaptor-related protein complex 2 subunit alpha-2|Alpha-adaptin C|Alpha2-adaptin|Clathrin assembly protein complex 2 alpha-C large chain|Huntingtin yeast partner J|Huntingtin-interacting protein 9 (HIP-9)|Huntingtin-interacting protein J|Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit|AP2A2|ADTAB|CLAPA2|HIP9|HYPJ|KIAA0899

Background: Component of the adaptor protein complex 2(AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin(clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein(AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV](Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif(By similarity).

Poids moléculaire: 104 kDa

ID gène: 161

UniProt: O94973

Pathways: EGFR Signaling Pathway, Neurotrophin Signaling Pathway, EGFR Downregulation, SARS-CoV-2 Protein Interactome