CD44 anticorps (AA 28-380)

N° du produit ABIN7112500

Cet anticorps Souris Monoclonal détecte spécifiquement CD44 dans FACS, WB, IHC, ELISA et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour CD44 anticorps (AA 28-380) (ABIN7112500)

Antigène: CD44

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD44 est non-conjugé

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Clone: 7D6

Détail du produit anti-CD44 anticorps

Épitope: AA 28-380

Fonction: CD44 antibody

Purification: Protein A+G purification

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: 28-380aa

Immunogen: CD44 molecule(Indian blood group)

Isotype: IgG2a

Information d'application

Indications d'application: WB: 1:500-1:5000, IHC: 1:50-1:200, IF: 1:10-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur CD44

Antigène: CD44

Autre désignation: CD44

Sujet:

Synonyms: CD44 antigen|CDw44|Epican|Extracellular matrix receptor III (ECMR-III)|GP90 lymphocyte homing/adhesion receptor|HUTCH-I|Heparan sulfate proteoglycan|Hermes antigen|Hyaluronate receptor|Phagocytic glycoprotein 1 (PGP-1)|Phagocytic glycoprotein I (PGP-I)|CD44|LHR|MDU2|MDU3|MIC4

Background: Receptor for hyaluronic acid(HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases(MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9, the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T(iTreg) cell stability and suppressive function(By similarity).

Poids moléculaire: 80-95 kDa

ID gène: 960

UniProt: P16070

Pathways: Glycosaminoglycan Metabolic Process, Autophagy, Negative Regulation of intrinsic apoptotic Signaling