CLASP2 anticorps

N° du produit ABIN7113293

L’anticorps anti-CLASP2 Polyclonal Lapin est utilisé pour la détection de CLASP2 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB et ELISA.

Aperçu rapide pour CLASP2 anticorps (ABIN7113293)

Antigène: CLASP2 (Cytoplasmic Linker Associated Protein 2 (CLASP2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CLASP2 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-CLASP2 anticorps

Fonction: CLASP2 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: cytoplasmic linker associated protein 2

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur CLASP2

Antigène: CLASP2 (Cytoplasmic Linker Associated Protein 2 (CLASP2))

Autre désignation: CLASP2

Sujet:

Synonyms: CLIP-associating protein 2|Cytoplasmic linker-associated protein 2|Protein Orbit homolog 2 (hOrbit2)|CLASP2|KIAA0627

Background: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules(PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network(TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2(PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle(PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.

Poids moléculaire: 140-160 kDa

ID gène: 23122

UniProt: O75122

Pathways: Dynamique des Microtubules, Maintenance of Protein Location