EPH Receptor A8 anticorps

N° du produit ABIN7113851

L’anticorps Lapin Polyclonal anti-EPH Receptor A8 a été validé pour ELISA et WB. Il convient pour détecter EPH Receptor A8 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour EPH Receptor A8 anticorps (ABIN7113851)

Antigène: EPH Receptor A8 (EPHA8)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EPH Receptor A8 est non-conjugé

Application: ELISA, Western Blotting (WB)

Détail du produit anti-EPH Receptor A8 anticorps

Fonction: EPHA8 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: EPH receptor A8

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur EPH Receptor A8

Antigène: EPH Receptor A8 (EPHA8)

Autre désignation: EPHA8

Sujet:

Synonyms: Ephrin type-A receptor 8|EPH- and ELK-related kinase|EPH-like kinase 3 (EK3, hEK3)|Tyrosine-protein kinase receptor EEK|EPHA8|EEK|HEK3|KIAA1459

Background: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth(By similarity).

Poids moléculaire: 120 kDa

ID gène: 2046

UniProt: P29322

Pathways: Signalisation RTK