FOXA2 anticorps

N° du produit ABIN7114288

Cet anticorps Lapin Polyclonal détecte spécifiquement FOXA2 dans WB, ELISA, IHC et IP. Il présente une réactivité envers Humain.

Aperçu rapide pour FOXA2 anticorps (ABIN7114288)

Antigène: FOXA2 (Forkhead Box A2 (FOXA2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FOXA2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Détail du produit anti-FOXA2 anticorps

Fonction: FOXA2 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: forkhead box A2

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:5000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:50-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur FOXA2

Antigène: FOXA2 (Forkhead Box A2 (FOXA2))

Autre désignation: FOXA2

Sujet:

Synonyms: Hepatocyte nuclear factor 3-beta (HNF-3-beta, HNF-3B)|Forkhead box protein A2|Transcription factor 3B (TCF-3B)|FOXA2|HNF3B|TCF3B

Background: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3'(By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs, FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis, regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.

Poids moléculaire: 60 kDa

ID gène: 3170

UniProt: Q9Y261

Pathways: Dopaminergic Neurogenesis, Regulation of Carbohydrate Metabolic Process