KIDINS220 anticorps

N° du produit ABIN7115686

Cet anticorps Lapin Polyclonal détecte spécifiquement KIDINS220 dans WB et ELISA. Il présente une réactivité envers Humain, Rat et Souris.

Aperçu rapide pour KIDINS220 anticorps (ABIN7115686)

Antigène: KIDINS220 (Kinase D-Interacting Substrate, 220kDa (KIDINS220))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KIDINS220 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-KIDINS220 anticorps

Fonction: KIDINS220 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: kinase D-interacting substrate, 220kDa

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur KIDINS220

Antigène: KIDINS220 (Kinase D-Interacting Substrate, 220kDa (KIDINS220))

Autre désignation: KIDINS220

Sujet:

Synonyms: Kinase D-interacting substrate of 220 kDa|Ankyrin repeat-rich membrane-spanning protein|KIDINS220|ARMS|KIAA1250

Background: Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor(NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin-and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration(By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.

Poids moléculaire: 186-197 kDa

ID gène: 57498

UniProt: Q9ULH0