HLA-A anticorps (AA 25-300)

N° du produit ABIN7116011

L’anticorps Souris Monoclonal anti-HLA-A a été validé pour FACS, WB, IHC et ELISA. Il convient pour détecter HLA-A dans des échantillons de Humain.

Aperçu rapide pour HLA-A anticorps (AA 25-300) (ABIN7116011)

Antigène: HLA-A (Major Histocompatibility Complex, Class I, A (HLA-A))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HLA-A est non-conjugé

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: 0D3

Détail du produit anti-HLA-A anticorps

Épitope: AA 25-300

Fonction: HLA-A antibody

Purification: Protein A+G purification

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: 25-300aa

Immunogen: major histocompatibility complex, class I, A

Isotype: IgG2a

Information d'application

Indications d'application: WB: 1:1000-1:8000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur HLA-A

Antigène: HLA-A (Major Histocompatibility Complex, Class I, A (HLA-A))

Autre désignation: HLA-A

Sujet:

Synonyms: HLA class I histocompatibility antigen, A alpha chain|Human leukocyte antigen A (HLA-A)|HLA-A|HLAA

Background: HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described.

Poids moléculaire: 44 kDa

ID gène: 3105

UniProt: P04439, P30443

Pathways: TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response