HLA-A anticorps

N° du produit ABIN7116012

Cet anticorps anti-HLA-A est un anticorps Lapin Polyclonal détectant HLA-A dans WB, IHC et ELISA. Adapté pour Humain et Souris.

Aperçu rapide pour HLA-A anticorps (ABIN7116012)

Antigène: HLA-A (Major Histocompatibility Complex, Class I, A (HLA-A))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HLA-A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-HLA-A anticorps

Fonction: HLA-A antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: A synthetic peptide

Immunogen: major histocompatibility complex, class I, A

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur HLA-A

Antigène: HLA-A (Major Histocompatibility Complex, Class I, A (HLA-A))

Autre désignation: HLA-A

Sujet:

Synonyms: HLA class I histocompatibility antigen, A alpha chain|Human leukocyte antigen A (HLA-A)|HLA-A|HLAA

Background: HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described.

Poids moléculaire: 44 kDa

ID gène: 3105

UniProt: P04439, P30443

Pathways: TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response