MEFV anticorps

N° du produit ABIN7116136

Cet anticorps Lapin Polyclonal détecte spécifiquement MEFV dans WB et ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour MEFV anticorps (ABIN7116136)

Antigène: MEFV (Mediterranean Fever (MEFV))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MEFV est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-MEFV anticorps

Fonction: MEFV antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: Mediterranean fever

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur MEFV

Antigène: MEFV (Mediterranean Fever (MEFV))

Autre désignation: MEFV

Sujet:

Synonyms: Pyrin|Marenostrin|MEFV|MEF|TRIM20

Background: Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B-and IL18-mediated inflammation(PubMed:16785446, PubMed:17431422, PubMed:26347139). However, it may also have a positive effect in the inflammatory pathway. In different experimental systems, it has been shown to activate IL1B production(PubMed:16037825). It has also been shown to be required for PSTPIP1-induced PYCARD oligomerization and for formation of inflammasomes. Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization(PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923).

Poids moléculaire: 86 kDa

ID gène: 4210

UniProt: O15553

Pathways: Positive Regulation of Endopeptidase Activity