Nischarin anticorps

N° du produit ABIN7116889

Cet anticorps Lapin Polyclonal détecte spécifiquement Nischarin dans WB, IP et ELISA. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour Nischarin anticorps (ABIN7116889)

Antigène: Nischarin (NISCH)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Nischarin est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), ELISA

Détail du produit anti-Nischarin anticorps

Fonction: NISCH antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: nischarin

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur Nischarin

Antigène: Nischarin (NISCH)

Autre désignation: NISCH

Sujet:

Synonyms: Nischarin|Imidazoline receptor 1 (I-1, IR1)|Imidazoline receptor antisera-selected protein (hIRAS)|Imidazoline-1 receptor (I1R)|Imidazoline-1 receptor candidate protein (I-1 receptor candidate protein, I1R candidate protein)|NISCH|IRAS|KIAA0975

Background: Acts either as the functional imidazoline-1 receptor(I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla(RVLM) neurons that exhibited rilmenidine-evoked hypotension(By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons(By similarity). Acts as a modulator of Rac-regulated signal transduction pathways(By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity(By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation(By similarity). Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation(By similarity). Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells(By similarity). Inhibits lamellipodia formation, when overexpressed(By similarity). Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures.

Poids moléculaire: 190-200 kDa

ID gène: 11188

UniProt: Q9Y2I1