PTBP1 anticorps

N° du produit ABIN7117687

Cet anticorps Lapin Polyclonal détecte spécifiquement PTBP1 dans WB, IHC et ELISA. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour PTBP1 anticorps (ABIN7117687)

Antigène: PTBP1 (Polypyrimidine Tract Binding Protein 1 (PTBP1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTBP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-PTBP1 anticorps

Fonction: PTBP1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: polypyrimidine tract binding protein 1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500 - 1:1000, IHC: 1:100 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur PTBP1

Antigène: PTBP1 (Polypyrimidine Tract Binding Protein 1 (PTBP1))

Autre désignation: PTBP1

Sujet:

Synonyms: Polypyrimidine tract-binding protein 1 (PTB)|57 kDa RNA-binding protein PPTB-1|Heterogeneous nuclear ribonucleoprotein I (hnRNP I)|PTBP1|PTB

Background: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.

Poids moléculaire: 57 kDa

ID gène: 5725

UniProt: P26599

Pathways: Regulation of Muscle Cell Differentiation