POFUT1 anticorps

N° du produit ABIN7117981

Cet anticorps Lapin Polyclonal détecte spécifiquement POFUT1 dans WB, IHC, ELISA, IP et IF. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour POFUT1 anticorps (ABIN7117981)

Antigène: POFUT1 (Protein O-Fucosyltransferase 1 (POFUT1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp POFUT1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF)

Détail du produit anti-POFUT1 anticorps

Fonction: POFUT1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: protein O-fucosyltransferase 1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur POFUT1

Antigène: POFUT1 (Protein O-Fucosyltransferase 1 (POFUT1))

Autre désignation: POFUT1

Sujet:

Synonyms: GDP-fucose protein O-fucosyltransferase 1|Peptide-O-fucosyltransferase 1 (O-FucT-1)|POFUT1|FUT12|KIAA0180

Background: Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors(AChRs).

Poids moléculaire: 44 kDa

ID gène: 23509

UniProt: Q9H488

Pathways: Signalisation Notch, SARS-CoV-2 Protein Interactome