ErbB2/Her2 anticorps

N° du produit ABIN7118347

Cet anticorps Lapin Polyclonal détecte spécifiquement ErbB2/Her2 dans WB, IHC, ELISA, FACS et IP. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour ErbB2/Her2 anticorps (ABIN7118347)

Antigène: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ErbB2/Her2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP)

Détail du produit anti-ErbB2/Her2 anticorps

Fonction: ERBB2 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog(avian)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:1000-1:10000, IP: 1:200-1:2000, IHC: 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur ErbB2/Her2

Antigène: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Autre désignation: ERBB2

Sujet:

Synonyms: Receptor tyrosine-protein kinase erbB-2|Metastatic lymph node gene 19 protein (MLN 19)|Proto-oncogene Neu|Proto-oncogene c-ErbB-2|Tyrosine kinase-type cell surface receptor HER2|p185erbB2|ERBB2|HER2|MLN19|NEU|NGL

Background: HER2, also known as ErbB2 and Neu, is a 185- kDa transmembrane glycoprotein that is a member of the epidermal growth factor(EGF) receptor family of receptor tyrosine kinases. It has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of HER2 have been reported in numerous cancers, including breast and ovarian tumors. HER2 is a therapeutic target for the treatment of breast cancer and other carcinomas. This antibody raised against a synthesized peptide corresponding to 1237-1255aa of human HER2 recognizes the 185- kDa full-length glycosylated form and other lower molecular-mass forms of HER2, including the truncated form.

Poids moléculaire: 185 kDa

ID gène: 2064

UniProt: P04626

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development