ARHGEF18 anticorps

N° du produit ABIN7118503

Cet anticorps Lapin Polyclonal détecte spécifiquement ARHGEF18 dans ELISA, WB et IHC. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour ARHGEF18 anticorps (ABIN7118503)

Antigène: ARHGEF18 (rho/rac Guanine Nucleotide Exchange Factor (GEF) 18 (ARHGEF18))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ARHGEF18 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-ARHGEF18 anticorps

Fonction: ARHGEF18 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: rho/rac guanine nucleotide exchange factor(GEF) 18

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur ARHGEF18

Antigène: ARHGEF18 (rho/rac Guanine Nucleotide Exchange Factor (GEF) 18 (ARHGEF18))

Autre désignation: ARHGEF18

Sujet:

Synonyms: Rho guanine nucleotide exchange factor 18|114 kDa Rho-specific guanine nucleotide exchange factor (p114-Rho-GEF, p114RhoGEF)|Septin-associated RhoGEF (SA-RhoGEF)|ARHGEF18|KIAA0521

Background: Acts as guanine nucleotide exchange factor(GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species(ROS). Does not act as a GEF for CDC42. The G protein beta-gamma(Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells(PubMed:22006950).

Poids moléculaire: 120-130 kDa

ID gène: 23370

UniProt: Q6ZSZ5

Pathways: Neurotrophin Signaling Pathway