RFFL anticorps

N° du produit ABIN7118629

Cet anticorps Lapin Polyclonal détecte spécifiquement RFFL dans WB et ELISA. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour RFFL anticorps (ABIN7118629)

Antigène: RFFL (Ring Finger and FYVE-Like Domain Containing 1 (RFFL))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RFFL est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-RFFL anticorps

Fonction: RFFL antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: ring finger and FYVE-like domain containing 1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur RFFL

Antigène: RFFL (Ring Finger and FYVE-Like Domain Containing 1 (RFFL))

Autre désignation: RFFL

Sujet:

Synonyms: E3 ubiquitin-protein ligase rififylin|Caspase regulator CARP2|Caspases-8 and -10-associated RING finger protein 2 (CARP-2)|FYVE-RING finger protein Sakura (Fring)|RING finger and FYVE-like domain-containing protein 1|RING finger protein 189|RING finger protein 34-like|RING-type E3 ubiquitin transferase rififylin|RFFL|RNF189|RNF34L

Background: E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling.

Poids moléculaire: 37-41 kDa

ID gène: 117584

UniProt: Q8WZ73