SLC5A8 anticorps

N° du produit ABIN7119316

Cet anticorps Lapin Polyclonal détecte spécifiquement SLC5A8 dans WB, ELISA et IF. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour SLC5A8 anticorps (ABIN7119316)

Antigène: SLC5A8 (Solute Carrier Family 5 (Iodide Transporter), Member 8 (SLC5A8))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLC5A8 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Détail du produit anti-SLC5A8 anticorps

Fonction: SLC5A8 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: solute carrier family 5(iodide transporter), member 8

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur SLC5A8

Antigène: SLC5A8 (Solute Carrier Family 5 (Iodide Transporter), Member 8 (SLC5A8))

Autre désignation: SLC5A8

Sujet:

Synonyms: Sodium-coupled monocarboxylate transporter 1|Apical iodide transporter|Electrogenic sodium monocarboxylate cotransporter|Sodium iodide-related cotransporter|Solute carrier family 5 member 8|SLC5A8|AIT|SMCT|SMCT1

Background: Acts as an electrogenic sodium(Na(+)) and chloride(Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates(short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs(nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies(beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons.

Poids moléculaire: 67 kDa

ID gène: 160728

UniProt: Q8N695