SYVN1 anticorps

N° du produit ABIN7119691

Cet anticorps Lapin Polyclonal détecte spécifiquement SYVN1 dans WB, ELISA, IHC et IP. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour SYVN1 anticorps (ABIN7119691)

Antigène: SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SYVN1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Détail du produit anti-SYVN1 anticorps

Fonction: SYVN1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: synovial apoptosis inhibitor 1, synoviolin

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur SYVN1

Antigène: SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))

Autre désignation: SYVN1

Sujet:

Synonyms: E3 ubiquitin-protein ligase synoviolin|RING-type E3 ubiquitin transferase synoviolin|Synovial apoptosis inhibitor 1|SYVN1|HRD1|KIAA1810

Background: Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control(ERQC) system also called ER-associated degradation(ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin(HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis.

Poids moléculaire: 68-76 kDa

ID gène: 84447

UniProt: Q86TM6

Pathways: ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling