SYVN1 anticorps (N-Term)

N° du produit ABIN1882139

Détail du produit anti-SYVN1 anticorps

Antigène: SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))

Épitope: AA 58-88, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SYVN1 est non-conjugé

Application: Western Blotting (WB)

Homologie: M, X

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This SYVN1 (HRD1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-88 amino acids from the N-terminal region of human SYVN1 (HRD1).

Clone: RB5086

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-SYVN1 (ABIN1882139)

Smith, Granell, Salcedo-Sicilia, Baldini, Egea, Teckman, Baldini: "Activating transcription factor 6 limits intracellular accumulation of mutant ?(1)-antitrypsin Z and mitochondrial damage in hepatoma cells." dans: The Journal of biological chemistry, Vol. 286, Issue 48, pp. 41563-77, (2011) (PubMed).

Klemm, Spooner, Ploegh: "Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control." dans: The Journal of biological chemistry, Vol. 286, Issue 43, pp. 37602-14, (2011) (PubMed).

Huang, Marvin, Tatsis, Eisenlohr: "Cutting Edge: Selective role of ubiquitin in MHC class I antigen presentation." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 4, pp. 1904-8, (2011) (PubMed).

Kikkert, Doolman, Dai, Avner, Hassink, van Voorden, Thanedar, Roitelman, Chau, Wiertz: "Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum." dans: The Journal of biological chemistry, Vol. 279, Issue 5, pp. 3525-34, (2004) (PubMed).

Amano, Yamasaki, Yagishita, Tsuchimochi, Shin, Kawahara, Aratani, Fujita, Zhang, Ikeda, Fujii, Miura, Komiya, Nishioka, Maruyama, Fukamizu, Nakajima: "Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy." dans: Genes & development, Vol. 17, Issue 19, pp. 2436-49, (2003) (PubMed).

Nadav, Shmueli, Barr, Gonen, Ciechanover, Reiss: "A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1." dans: Biochemical and biophysical research communications, Vol. 303, Issue 1, pp. 91-7, (2003) (PubMed).

Détails sur SYVN1

Antigène: SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))

Autre désignation: SYVN1 (HRD1) (SYVN1 Produits)

Synonymes: anticorps DER3, anticorps HRD1, anticorps hrd1, anticorps 1200010C09Rik, anticorps AW211966, anticorps C85322, anticorps D530017H19Rik, anticorps Hrd1, anticorps RGD1310488, anticorps syvn1, anticorps syvn1-a, anticorps syvn1-b, anticorps wu:fk91f10, anticorps zgc:55735, anticorps zgc:77108, anticorps synoviolin 1, anticorps synovial apoptosis inhibitor 1, synoviolin, anticorps synoviolin 1 S homeolog, anticorps SYVN1, anticorps syvn1, anticorps Syvn1, anticorps syvn1.S

Sujet: HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. Synoviolin/Hrd1 (expressed in rheumatoid synovium) is reported to be a novel causative factor for arthropathy by triggering synovial cell outgrowth through its antiapoptotic effects. HRD1 contains one ring-type zinc finger.

Poids moléculaire: 67685

NCBI Accession: NP_115807, NP_757385

UniProt: Q86TM6

Pathways: ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling