TNIP1 anticorps

N° du produit ABIN7119995

L’anticorps Lapin Polyclonal anti-TNIP1 a été validé pour WB, ELISA, IHC, IF et IP. Il convient pour détecter TNIP1 dans des échantillons de Humain.

Aperçu rapide pour TNIP1 anticorps (ABIN7119995)

Antigène: TNIP1 (TNFAIP3 Interacting Protein 1 (TNIP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TNIP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Détail du produit anti-TNIP1 anticorps

Fonction: TNIP1 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: TNFAIP3 interacting protein 1

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur TNIP1

Antigène: TNIP1 (TNFAIP3 Interacting Protein 1 (TNIP1))

Autre désignation: TNIP1

Sujet:

Synonyms: TNFAIP3-interacting protein 1|A20-binding inhibitor of NF-kappa-B activation 1 (ABIN-1)|HIV-1 Nef-interacting protein|Nef-associated factor 1 (Naf1)|Nip40-1|Virion-associated nuclear shuttling protein (VAN, hVAN)|TNIP1|KIAA0113|NAF1

Background: Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG, proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway, blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity, this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation, this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC(Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection.

Poids moléculaire: 72 kDa

ID gène: 10318

UniProt: Q15025

Pathways: Activation of Innate immune Response