Tubulin anticorps (acLys40)

N° du produit ABIN7120355

L’anticorps Souris Monoclonal anti-Tubulin a été validé pour WB, IF, ELISA et IHC. Il convient pour détecter Tubulin dans des échantillons de Humain, Souris, Chien et Rat.

Aperçu rapide pour Tubulin anticorps (acLys40) (ABIN7120355)

Antigène: Tubulin (TUB)

Reactivité: Humain, Souris, Chien, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Tubulin est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunohistochemistry (IHC)

Clone: 6A10

Détail du produit anti-Tubulin anticorps

Épitope: acLys40

Fonction: Acetylated tubulin antibody

Purification: Protein A+G purification

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: A synthetic peptide(1-50aa)

Immunogen: tubulin, alpha 1a

Isotype: IgG1

Information d'application

Indications d'application: WB: 1:500-1:5000, IF: 1:20-1:200, IHC: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur Tubulin

Antigène: Tubulin (TUB)

Autre désignation: tubulin

Sujet:

Synonyms: Tubulin alpha-1A chain|Alpha-tubulin 3|Tubulin B-alpha-1|Tubulin alpha-3 chain|Detyrosinated tubulin alpha-1A chain|TUBA1A|TUBA3

Background: Tubulin, composed of heterodimers of alpha and beta tubulin, is the mainly component of microtubules which play important roles in cell motility, mitosis, and intracellular vesicle transport. Both alpha and beta tubulin undergo several posttranslational modifications such as polyglutamylation and acetylation/deacetylation. Tubulin acetylation occurs on lysine-40 at the N-terminal of alpha tubulin and is conserved across species. The histone deacetylase HDAC6 and SIRT2 has been identified as tubulin deacetylases. Reversible acetylation of alpha tubulin may be implicated in regulating microtubule stability, cell motility, and axon regeneration. The level of acetylated tubulin has been linked to epithelial malignancies and sensitivity to chemotherapy. In addition, acetylated tubulin has been widely used as a marker for primary cilia. This antibody is specific to the acetylated tubulin, it does not recognize non-acetylated tubulin.

Poids moléculaire: 52 kDa

ID gène: 7846

UniProt: Q71U36