ZCCHC11 anticorps

N° du produit ABIN7121051

L’anticorps Lapin Polyclonal anti-ZCCHC11 a été validé pour WB, ELISA, IF et IP. Il convient pour détecter ZCCHC11 dans des échantillons de Humain et Souris.

Aperçu rapide pour ZCCHC11 anticorps (ABIN7121051)

Antigène: ZCCHC11 (Zinc Finger, CCHC Domain Containing 11 (ZCCHC11))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZCCHC11 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)

Détail du produit anti-ZCCHC11 anticorps

Fonction: TUT4 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: zinc finger, CCHC domain containing 11

Isotype: IgG

Information d'application

Indications d'application: WB: 1:200-1:2000, IP: 1:500-1:5000, IF: 1:20-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur ZCCHC11

Antigène: ZCCHC11 (Zinc Finger, CCHC Domain Containing 11 (ZCCHC11))

Autre désignation: TUT4

Sujet:

Synonyms: Terminal uridylyltransferase 4 (TUTase 4)|Zinc finger CCHC domain-containing protein 11|TUT4|KIAA0191|ZCCHC11

Background: Uridylyltransferase that mediates the terminal uridylation of mRNAs with short(less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay(PubMed:25480299). Involved in microRNA(miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7(pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem(ES) cell pluripotency(By similarity). Does not bind RNA directly, but recruited to RNA targets by RNA-binding protein LIN28A. Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression(By similarity). May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation. Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult.

Poids moléculaire: 185 kDa

ID gène: 23318

UniProt: Q5TAX3

Pathways: Stem Cell Maintenance