alpha 2 Macroglobulin anticorps (AA 604-748)

N° du produit ABIN7126326

L’anticorps anti-alpha 2 Macroglobulin Monoclonal Souris est utilisé pour la détection de alpha 2 Macroglobulin dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour alpha 2 Macroglobulin anticorps (AA 604-748) (ABIN7126326)

Antigène: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp alpha 2 Macroglobulin est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: A2M-3621

Détail du produit anti-alpha 2 Macroglobulin anticorps

Épitope: AA 604-748

Fonction: Alpha-2-Macroglobulin Antibody

Specificité: °™-2-Macroglobulin (°™-2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, °™-2M was characterized as a pan-proteinase inhibitor that was able to bait proteinases into cleaving specific peptide sequences on °™-2M. This interaction induces a conformational change in °™-2M, thus enabling it to trap the proteinase and further inhibit its activity. Subsequently, °™-2M has been shown to function as a carrier protein and regulator of cytokines during inflammation. Circulating transforming growth factor æ (TGF æ) in serum is primarily bound to °™-2M, which renders TGF æ inactive. °™-2M also binds to IL-6 and, thereby, increases the concentration of IL-6 near lymphocytes, hepatocytes and stem cells involved in mediating the inflammatory cascade. Mutations and deletions in the gene encoding °™-2M are associated with an increased incidence of Alzheimer s disease (AD), which is consistent with the role of °™-2M in mediating the clearance and degradation of A æ, the major component of æ-Amyloid deposits accumulated during AD.

Réactivité croisée (Details): Human.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Human recombinant A2M protein fragment (around aa604-748) (exact sequence is proprietary)

Isotype: IgG2c, kappa

Information d'application

Indications d'application:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Human liver or placenta tissues.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur alpha 2 Macroglobulin

Antigène: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Autre désignation: A2M

Sujet:

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, Alpha-2-M (A2M), CPAMD5

Human liver or placenta tissues.

Poids moléculaire: 185kDa

ID gène: 2, 212838

UniProt: P01023

Pathways: Lipid Metabolism