IGF1R anticorps (AA 550-750)

N° du produit ABIN7126548

L’anticorps Souris Monoclonal anti-IGF1R a été validé pour IF, FACS, Neut, AcA et in vitro. Il convient pour détecter IGF1R dans des échantillons de Humain.

Aperçu rapide pour IGF1R anticorps (AA 550-750) (ABIN7126548)

Antigène: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IGF1R est non-conjugé

Application: Immunofluorescence (IF), Flow Cytometry (FACS), Neutralization (Neut), Activity Assay (AcA), In vitro Assay (in vitro)

Détail du produit anti-IGF1R anticorps

Épitope: AA 550-750

Specificité: Receptor tyrosine kinases (RTKs) are transmembrane molecular scaffolds that influence cellular processes including the cell cycle, cell migration, cell metabolism, cell survival, proliferation and differentiation. Insulin-like growth factor-I receptor (IGF-IR) is an RTK that stimulates growth in many different cell types, blocks apoptosis, acts as an intermediate of many growth hormone responses and may stimulate the growth of some types of cancer. The IGF-IR cognate ligand Insulin-like growth factor-I (IGF-I) promotes association of IGF-IR with Shc, GRB2 and Sos 1, which initiates Ras and ERK kinase cascades, thereby modifying transcription factor activity, such as activation of the Elk transcription factors. The modular phosphotyrosine binding (PTB) domains of Insulin receptor substrate (IRS)-1 and -2 can associate with active IGF-IR and initiate phosphatidylinositol 3-kinase-dependent downstream signals. The human IGF-IR gene maps to chromosome 15q26.3 and encodes a 1,376 amino acid precursor protein that cleaves into i± and i² subunits. The human IGF-IIR gene maps to chromosome 6q26 and encodes a 2,491 amino acid transmembrane protein.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant fragment (around aa550-750) of human IGF1R protein (exact sequence is proprietary)

Isotype: IgG2

Information d'application

Indications d'application:

Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-4 μg/mL), In-vitro Neutralization of Biological Activity of IGF-1 (Order Ab without Azide)Optimal dilution for a specific application should be determined.

Positive_Control: Human breast carcinoma or colon carcinoma.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur IGF1R

Antigène: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Autre désignation: IGF1R

Sujet: CD221 antigen, IGF 1 receptor, IGF 1R, IGFIR, IGFIRC, IGFR, Insulin like growth factor 1 receptor precursor, Insulin-like growth factor 1 receptor beta chain, JTK13, Soluble IGF1R variant 1, Soluble IGF1R variant 2,IGF1R / CD221
Cellular localisation: Cell membrane.

Poids moléculaire: 130kDa (IGF-1R), 97kDa (IGF-1R), 200kDa (pro-IGF-1R)

ID gène: 3480, 643120, 714012

UniProt: P08069

Pathways: Signalisation RTK, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy