RAC1 anticorps

N° du produit ABIN7126866

Détail du produit anti-RAC1 anticorps

Antigène: RAC1

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp RAC1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Coating (Coat), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificité: Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages (By similarity). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Rac1 has been demonstrated to play a critical role in tumor progression of human colorectal adenocarcinoma cells. In one study, overexpression of Rac1 accelerated the tumorigenic process, whereas Rac1 inhibition completed suppressed tumor formation.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant human full-length RAC1protein

Isotype: IgG1

Information d'application

Indications d'application:

Known_Application: ELISA (For coating, order antibody without BSA), Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL), ,Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: HeLa or Jurkat cells. Human breast, prostate or tonsil tissues.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur RAC1

Antigène: RAC1

Abstract: RAC1 Produits

Synonymes: anticorps Rac-1, anticorps TC-25, anticorps p21-Rac1, anticorps AL023026, anticorps D5Ertd559e, anticorps RAC2, anticorps CRAC1A, anticorps rac1, anticorps wu:fd16e02, anticorps zgc:55823, anticorps zgc:55917, anticorps zgc:86934, anticorps 2248, anticorps CG2248, anticorps D-Rac, anticorps D-Rac 1, anticorps D-Rac1, anticorps DRac, anticorps DRac1, anticorps DRacA, anticorps Dm Rac1, anticorps DmRAC, anticorps DmRAC1, anticorps Dmel\CG2248, anticorps Dmrac1, anticorps Drac, anticorps Drac1, anticorps Drac1a, anticorps DracA, anticorps GTPase Rac1, anticorps P40792, anticorps RAC1, anticorps Rac, anticorps Rac GTPase, anticorps Rac3, anticorps RacA, anticorps dRac, anticorps dRac1, anticorps drac1, anticorps rac, anticorps Xrac, anticorps mig5, anticorps p21-rac1, anticorps tc-25, anticorps Rac family small GTPase 1, anticorps RAS-related C3 botulinum substrate 1, anticorps ras-related C3 botulinum toxin substrate 1, anticorps ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1), anticorps Rac family small GTPase 1a, anticorps CG2248 gene product from transcript CG2248-RB, anticorps Rac family small GTPase 1 L homeolog, anticorps ras homolog family member G, anticorps RAC1, anticorps Rac1, anticorps rac1a, anticorps rac1.L, anticorps RHOG

Sujet: Cell migration-inducing gene 5 protein, MIG5, Rac-1, Ras-like protein TC25, Ras-related C3 botulinum toxin substrate 1,Ras-related C3 botulinum toxin substrate 1
Cellular localisation: Cell surface. Melanosome.

Poids moléculaire: 21kDa

ID gène: 5879, 413812

UniProt: P63000

Pathways: Signalisation WNT, Regulation of Actin Filament Polymerization, Cell-Cell Junction Organization, Thromboxane A2 Receptor Signaling, VEGF Signaling