MSK1 anticorps

N° du produit ABIN7127155

L’anticorps anti-MSK1 Monoclonal Souris est utilisé pour la détection de MSK1 dans des échantillons de Humain. Il a été validé pour WB, IF et FACS.

Aperçu rapide pour MSK1 anticorps (ABIN7127155)

Antigène: MSK1 (RPS6KA5) (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MSK1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: PCRP-RPS6KA5-1A8

Détail du produit anti-MSK1 anticorps

Fonction: RPS6KA5 / MSK1 Antibody

Specificité: The family of ribosomal S6 kinases (Rsks), designated Rsk-1, Rsk-2 and Rsk-3, have been implicated as important signaling intermediates in response to a broad range of ligand-activated receptor tyrosine kinases. A unique feature common to the three members of the Rsk family is that each possesses two non-identical complete kinase catalytic domains. A related S6 kinase, p70 S6 kinase, functions to phosphorylate the S6 protein on ribosomal 40S subunits. p70 S6 kinase b shares high sequence homology with p70 S6 kinase, except in the carboxy terminus where it contains a proline-rich domain that may be involved in SH3 domain containing protein interactions. MSK1 (also designated RLPK) is related to Rsk and p70 S6 kinase family members and is thought to be structurally similar to Rsk family members, but it may be regulated by distinct mechanisms.

Réactivité croisée (Details): Human. Predicted to react with Mouse and Rat.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant full-length human RPS6KA5 protein

Isotype: IgG2b

Information d'application

Indications d'application:

Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), ,Western Blot (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

Positive_Control: HeLa or JAR cells. Ubiquitous nuclear expression. Human prostate, tonsil or brain.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur MSK1

Antigène: MSK1 (RPS6KA5) (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5))

Autre désignation: RPS6KA5

Sujet:

90 kDa ribosomal protein S6 kinase 5, EC 2.7.11.1, Mitogen and stress activated protein kinase 1, MSPK1, Nuclear Mitogen And Stress Activated Protein Kinase 1, Ribosomal protein S6 kinase 90kD polypeptide 5, Ribosomal Protein S6 Kinase Alpha 5, RLPK, RPS6KA5, RSK Like Protein Kinase, RSKL, S6K alpha 5

HeLa or JAR cells. Ubiquitous nuclear expression. Human prostate, tonsil or brain.

Poids moléculaire: ~90kDa

ID gène: 9252, 510225

UniProt: O75582

Pathways: Signalisation MAPK, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades