Recombinant FOXO3 anticorps

N° du produit ABIN7127500

Détail du produit anti-FOXO3 anticorps

Antigène: FOXO3 (Forkhead Box O3 (FOXO3))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp FOXO3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human FOXO3

Clone: 1E2

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200, IF:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur FOXO3

Antigène: FOXO3 (Forkhead Box O3 (FOXO3))

Autre désignation: FOXO3 (FOXO3 Produits)

Synonymes: anticorps AF6q21, anticorps FKHRL1, anticorps FKHRL1P2, anticorps FOXO2, anticorps FOXO3A, anticorps zgc:92176, anticorps wu:fb50g02, anticorps wu:fi33f07, anticorps Fkhrl1, anticorps Foxo3a, anticorps FoxO3A, anticorps 1110048B16Rik, anticorps 2010203A17Rik, anticorps C76856, anticorps Fkhr2, anticorps FOXO-3, anticorps FOXO3, anticorps foxo3a, anticorps xfoxo3, anticorps foxO3, anticorps foxO, anticorps fkhr, anticorps foxo5, anticorps wu:fj65a12, anticorps zFkhr, anticorps forkhead box O3, anticorps forkhead box O3A, anticorps forkhead box O3 L homeolog, anticorps forkhead box O3b, anticorps FOXO3, anticorps foxo3a, anticorps Foxo3, anticorps foxo3.L, anticorps foxo3, anticorps foxO3, anticorps foxo3b

Sujet:

Background: Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' (PubMed:21329882). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301).

Aliases: Forkhead box protein O3, AF6q21 protein, FOXO3

UniProt: O43524

Pathways: Cycle Cellulaire, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis