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Recombinant PIK3CB anticorps

PIK3CB Reactivité: Humain WB, ELISA, IP Hôte: Lapin Monoclonal 5A9 unconjugated Recombinant Antibody
N° du produit ABIN7127763
  • Antigène Voir toutes PIK3CB Anticorps
    PIK3CB (Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide (PIK3CB))
    Type d'anticorp
    Recombinant Antibody
    Reactivité
    • 102
    • 39
    • 39
    • 18
    • 18
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 98
    • 4
    Lapin
    Clonalité
    • 89
    • 12
    Monoclonal
    Conjugué
    • 34
    • 13
    • 10
    • 8
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp PIK3CB est non-conjugé
    Application
    • 82
    • 45
    • 34
    • 26
    • 26
    • 16
    • 15
    • 6
    • 5
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunoprecipitation (IP)
     Réactivité croisée
    Humain
    Purification
    Affinity-chromatography
    Immunogène
    A synthesized peptide derived from human PI3 Kinase p110 beta
    Clone
    5A9
    Isotype
    IgG
    Top Product
    Discover our top product PIK3CB Anticorps primaire
  • Indications d'application
    Recommended dilution: WB:1:500-1:5000, IP:1:200-1:1000,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    PIK3CB (Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide (PIK3CB))
    Autre désignation
    PIK3CB (PIK3CB Produits)
    Synonymes
    anticorps P110BETA, anticorps PI3K, anticorps PI3KBETA, anticorps PIK3C1, anticorps fb92a07, anticorps wu:fb92a07, anticorps 1110001J02Rik, anticorps AI447572, anticorps p110beta, anticorps PI3Kbeta, anticorps phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta, anticorps phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta, anticorps PIK3CB, anticorps pik3cb, anticorps Pik3cb
    Sujet

    Background: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors.

    Aliases: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta), PIK3CB, PIK3C1

    UniProt
    P42338
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